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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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NFKBIZ

Introduction

NF-kappa-B inhibitor zeta is a protein that in humans is encoded by the NFKBIZ gene.[1][2][3]

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

References

  1. ↑ Eto A, Muta T, Yamazaki S, Takeshige K (Feb 2003). “Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta”. Biochem Biophys Res Commun. 301 (2): 495–501. doi:10.1016/S0006-291X(02)03082-6. PMID 12565889.
  2. ↑ Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K (May 2006). “A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding”. J Biol Chem. 281 (18): 12645–54. doi:10.1074/jbc.M511956200. PMID 16513645.
  3. ↑ 3.0 3.1 “Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta”.
Further reading

Further reading

  • Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (2000). “MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production”. FEBS Lett. 485 (1): 53–6. doi:10.1016/S0014-5793(00)02185-2. PMID 11086164.
  • Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (2001). “Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene”. Immunogenetics. 53 (8): 649–55. doi:10.1007/s00251-001-0376-x. PMID 11797098.
  • Haruta H, Kato A, Todokoro K (2001). “Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs”. J. Biol. Chem. 276 (16): 12485–8. doi:10.1074/jbc.C100075200. PMID 11278262.
  • Yamazaki S, Muta T, Takeshige K (2001). “A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei”. J. Biol. Chem. 276 (29): 27657–62. doi:10.1074/jbc.M103426200. PMID 11356851.
  • Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (2002). “Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4”. J. Vet. Med. Sci. 64 (5): 419–22. doi:10.1292/jvms.64.419. PMID 12069074.
  • Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (2003). “Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages”. Arch. Histol. Cytol. 66 (1): 53–62. doi:10.1679/aohc.66.53. PMID 12703554.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (2004). “Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease”. J. Biol. Chem. 279 (53): 55493–8. doi:10.1074/jbc.M409770200. PMID 15491998.
  • Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (2004). “Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages”. Gene. 342 (1): 137–43. doi:10.1016/j.gene.2004.07.032. PMID 15527973.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). “Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta”. Nature. 430 (6996): 218–22. doi:10.1038/nature02738. PMID 15241416.
  • Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (2004). “Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows”. Vet. Immunol. Immunopathol. 98 (3–4): 175–84. doi:10.1016/j.vetimm.2003.12.004. PMID 15010226.
  • Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). “Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization”. J. Biol. Chem. 280 (2): 1678–87. doi:10.1074/jbc.M409983200. PMID 15522867.
  • Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). “Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein”. J. Biol. Chem. 280 (9): 7444–51. doi:10.1074/jbc.M412738200. PMID 15618216.
  • Cowland JB, Muta T, Borregaard N (2006). “IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta”. J. Immunol. 176 (9): 5559–66. doi:10.4049/jimmunol.176.9.5559. PMID 16622025.
  • Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (2007). “Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes”. J Vet Med Sci. 69 (3): 279–84. doi:10.1292/jvms.69.279. PMID 17409644.
  • Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). “Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation”. Biochem. J. 405 (3): 605–15. doi:10.1042/BJ20061797. PMC 2267307. PMID 17447895.