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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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NID2

Introduction

Nidogen 2 (osteonidogen), also known as NID2, is a human gene.[1]

Basement membranes, which are composed of type IV collagens (see MIM 120130), laminins (see LAMC1; MIM 150290), perlecan (HSPG2; MIM 142461), and nidogen (see NID1; MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis.[supplied by OMIM][1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: NID2 nidogen 2 (osteonidogen)”.
Further reading

Further reading

  • Ulazzi L, Sabbioni S, Miotto E; et al. (2007). “Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer”. Mol. Cancer. 6: 17. doi:10.1186/1476-4598-6-17. PMID 17328794.
  • Nischt R, Schmidt C, Mirancea N; et al. (2007). “Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture”. J. Invest. Dermatol. 127 (3): 545–54. doi:10.1038/sj.jid.5700562. PMID 17008882.
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Miosge N, Sasaki T, Timpl R (2003). “Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice”. Matrix Biol. 21 (7): 611–21. PMID 12475645.
  • Miosge N, Holzhausen S, Zelent C; et al. (2002). “Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development”. Histochem. J. 33 (9–10): 523–30. PMID 12005023.
  • Tu H, Sasaki T, Snellman A; et al. (2002). “The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin”. J. Biol. Chem. 277 (25): 23092–9. doi:10.1074/jbc.M107583200. PMID 11956183.
  • Sasaki T, Göhring W, Mann K; et al. (2002). “Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins”. J. Mol. Biol. 314 (4): 751–63. doi:10.1006/jmbi.2001.5176. PMID 11733994.
  • Sasaki T, Göhring W, Miosge N; et al. (1999). “Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins”. FEBS Lett. 460 (2): 280–4. PMID 10544250.
  • Kohfeldt E, Sasaki T, Göhring W, Timpl R (1998). “Nidogen-2: a new basement membrane protein with diverse binding properties”. J. Mol. Biol. 282 (1): 99–109. doi:10.1006/jmbi.1998.2004. PMID 9733643.
  • Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. PMID 8889548.

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