Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
NPW
Introduction
Neuropeptide W is a protein that in humans is encoded by the NPW gene.[1][2][3]
Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM][3]
References
References
- ↑ Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M (Sep 2002). “Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7”. J Biol Chem. 277 (37): 34010–6. doi:10.1074/jbc.M205883200. PMID 12118011.
- ↑ Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M (Jan 2003). “Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8”. J Biol Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
- ↑ 3.0 3.1 “Entrez Gene: NPW neuropeptide W”.
Further reading
Further reading
- Singh G, Davenport AP (2006). “Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system”. Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Shimomura Y, Harada M, Goto M, et al. (2002). “Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8”. J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tanaka H, Yoshida T, Miyamoto N, et al. (2003). “Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8”. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
- Mondal MS, Yamaguchi H, Date Y, et al. (2003). “A role for neuropeptide W in the regulation of feeding behavior”. Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
- Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). “G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades”. J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
- Andreis PG, Rucinski M, Neri G, et al. (2006). “Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects”. Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
- Mondal MS, Yamaguchi H, Date Y, et al. (2006). “Neuropeptide W is present in antral G cells of rat, mouse, and human stomach”. J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.