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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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NRP2

Introduction

Neuropilin 2, also known as NRP2, is a human gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[1]

References

References

  1. ↑ “Entrez Gene: NRP2 neuropilin 2”.
Further reading

Further reading

  • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). “Vascular endothelial growth factor (VEGF) and its receptors”. FASEB J. 13 (1): 9–22. PMID 9872925.
  • Kolodkin AL, Levengood DV, Rowe EG; et al. (1997). “Neuropilin is a semaphorin III receptor”. Cell. 90 (4): 753–62. PMID 9288754.
  • Chen H, Chédotal A, He Z; et al. (1997). “Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III”. Neuron. 19 (3): 547–59. PMID 9331348.
  • Giger RJ, Urquhart ER, Gillespie SK; et al. (1999). “Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity”. Neuron. 21 (5): 1079–92. PMID 9856463.
  • Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). “Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins”. Neuron. 21 (6): 1283–90. PMID 9883722.
  • Takahashi T, Nakamura F, Jin Z; et al. (1999). “Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors”. Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
  • Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). “Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively”. Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
  • Tamagnone L, Artigiani S, Chen H; et al. (1999). “Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates”. Cell. 99 (1): 71–80. PMID 10520995.
  • Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). “Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]”. J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
  • Handa A, Tokunaga T, Tsuchida T; et al. (2000). “Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma”. Int. J. Oncol. 17 (2): 291–5. PMID 10891538.
  • Rossignol M, Gagnon ML, Klagsbrun M (2001). “Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms”. Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
  • Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). “Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes”. J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
  • Cohen T, Gluzman-Poltorak Z, Brodzky A; et al. (2001). “Neuroendocrine cells along the digestive tract express neuropilin-2”. Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
  • Herzog Y, Kalcheim C, Kahane N; et al. (2002). “Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins”. Mech. Dev. 109 (1): 115–9. PMID 11677062.
  • Oh H, Takagi H, Otani A; et al. (2002). “Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis”. Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMID 11756651.
  • Fakhari M, Pullirsch D, Abraham D; et al. (2002). “Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma”. Cancer. 94 (1): 258–63. PMID 11815985.
  • Cohen T, Herzog Y, Brodzky A; et al. (2002). “Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours”. J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.
  • Kawakami T, Tokunaga T, Hatanaka H; et al. (2003). “Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma”. Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

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