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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Naphthylisopropylamine

Introduction

Naphthylisopropylamine (PAL-287) is a stimulant drug developed for the treatment of amphetamine and cocaine addiction. PAL-287 acts by releasing dopamine and serotonin.[1]

In animal studies, PAL-287 was shown to reduce cocaine self-administration, yet produced relatively little stimulant effect when administered by itself, being a weaker stimulant than the comparison drug dexamphetamine.[2] PAL-287 is now under development to see whether it is a useful substitute drug for treating stimulant addiction in humans.

References

  1. ↑ Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.
  2. ↑ Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth, and Michael H. Baumann. Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration. Journal of Pharmacology And Experimental Therapeutics. 2005; 313: 1361-1369.

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