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Neber rearrangement
Introduction
The Neber rearrangement is an organic reaction in which an oxime is converted into an alpha-aminoketone in a rearrangement reaction.[1][2]
The oxime is first converted to a ketoxime tosylate by reaction with tosyl chloride. Added base forms a carbanion which displaces the tosylate group in a nucleophilic displacement to a azirine and added water subsequently hydrolyses it to the aminoketone.
The Beckmann rearrangement is a side reaction.
References
- ↑ Template:JerryMarch
- ↑ P. W. Neber and A. v. Friedolsheim (1926). “Über eine neue Art der Umlagerung von Oximen”. Justus Liebig’s Annalen der Chemie. 449 (1): 109–134. doi:10.1002/jlac.19264490108.