Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Neonatal alloimmune thrombocytopenia causes
Introduction
Overview
Overview
Causes
Causes
About 80% of cases of NAIT are caused by antibodies against platelet antigen HP-1a, 15% by anti-HP-5a, and 5% by other antibodies. Unlike the hemolytic disease, NAIT occurs during the first pregnancy in to 50% of cases, and the affected fetuses may develop severe thrombocytopenia (<50,000 /μL) very early during pregnancy. Usually, the thrombocytopenia increases as gestation progresses.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]