Neonatal jaundice risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Common risk factors for neonatal jaundice include maternal risk factors and neonatal risk factors. Common maternal risk factors include mother of Asian race, usage of oxytocin during labor, exclusive breastfeeding, and prolonged labor. Neonatal risk factors include family history of siblings received phototherapy, ABO blood group incompatiblity, preterm neonates, and cephalhematoma. Less common risk factors for neonatal jaundice include maternal age more than 25 years, siblings with jaundice, male neonates, and black race neonates.

Risk Factors

Common risk factors

Common risk factors for neonatal jaundice include the following:^[1]^[2]

Maternal risk factors	Neonatal risk factors
Asian race Usage of oxytocin during labor Exclusive breastfeeding Herbal drug during pregnancy Prolonged labor	Family history of siblings received phototherapy Developing jaundice in the first 24 hours of delivery is an indicator of severe hyperbilirubinemia ABO blood group incompatibility Preterm neonates Cephalhematoma

Less common risk factors

Less common risk factors for neonatal jaundice include the following:
- Maternal age more than 25 years
- Siblings with jaundice
- Predischarge total bilirubin in the intermediate high risk zone
- Male neonates
- Black race neonates

References

↑ Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS (2004). “Risk factors for severe hyperbilirubinemia in neonates”. Pediatr Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464.
↑ Olusanya BO, Osibanjo FB, Slusher TM (2015). “Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis”. PLoS One. 10 (2): e0117229. doi:10.1371/journal.pone.0117229. PMC 4326461. PMID 25675342.

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[pmid15319464-1] Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS (2004). “Risk factors for severe hyperbilirubinemia in neonates”. Pediatr Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464.

[pmid25675342-2] Olusanya BO, Osibanjo FB, Slusher TM (2015). “Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis”. PLoS One. 10 (2): e0117229. doi:10.1371/journal.pone.0117229. PMC 4326461. PMID 25675342.

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