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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Neoplastic meningitis MRI

Introduction

Overview

Overview

Brain MRI is helpful in the diagnosis of neoplastic meningitis. On MRI, neoplastic meningitis is characterized by normal T1- and T2-weighted images. On contrast administration, there may be leptomeningeal enhancement scattered over the brain in a ‘sugar coated’ manner, which is fairly diagnostic for neoplastic meningitis.[1]

MRI [2]

MRI [2]

  • Brain MRI is helpful in the diagnosis of neoplastic meningitis with sensitivity and specificity estimated to be around 66-98% and 77-97.7% respectively.
  • The most sensitive MRI component are contrast-enhanced T1 weight and fluid attenuated inversion recovery (FLAIR) sequences.
  • Findings that are fairly suggestive of neoplastic meningitis include nodular meningeal tumor, meningeal thickening > 3 mm, and a subjectively strong contrast enhancement. A smooth contrast enhancement of the meninges is typical for inflammatory, nonneoplastic meningitis.[3]
  • On MRI, neoplastic meningitis is characterized by:[1]
MRI component Findings

T1

  • Usually normal

T2

  • Usually normal

T1 with contrast

  • Leptomeningeal enhancement scattered over the brain in a ‘sugar coated’ manner (diagnostic)

Fluid-attenuated inversion recovery
(FLAIR)

  • Abnormally elevated signal within sulci
References

References

  1. ↑ 1.0 1.1 Radiographic features of leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 19, 2016
  2. ↑ Pellerino, Alessia (March 2018). “Neoplastic meningitis in solid tumors: from diagnosis to personalized treatments”. Therapeutic Advances in Neurological Disorders. 11.
  3. ↑ Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]