Neoplastic meningitis epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Neoplastic meningitis occurs in approximately 3000-5000 of 100,000 patients with solid tumors, 5000-15,000 of 100,000 patients with leukemia, and 1000-2000 of 100,000 patients with primary brain tumors.^[1]^[2]

Epidemiology and Demographics

Incidence

Neoplastic meningitis occurs in approximately 3000-5000 of 100,000 patients with solid tumors.
Neoplastic meningitis occurs in approximately 5000-15,000 of 100,000 patients with leukemia.
Neoplastic meningitis occurs in approximately 1000-2000 of 100,000 patients with primary brain tumors.^[1]^[2]

Prevalence

Observational studies show that neoplastic meningitis develop in 1-5% of solid tumors, of which adenocarcinoma is the most frequently observed histology.
Neoplastic meningitis typically develop in the setting of an advanced stage and widely disseminated cancer in 70% of the cases. It can also present during the patients disease-free interval or remission in 20% of the time, and even be the first manifestation of cancer (5-10%) occasionally.^[3]

Age

Neoplastic meningitis occurs more in elderly people, as it is associated with other primary cancer development.

References

↑ ^1.0 ^1.1 Gleissner, Beate; Chamberlain, Marc Charles (2006). “Neoplastic meningitis”. The Lancet Neurology. 5 (5): 443–452. doi:10.1016/S1474-4422(06)70443-4. ISSN 1474-4422.
↑ ^2.0 ^2.1 Hayat, M. A. Brain metastases from primary tumors : epidemiology, biology, and therapy. London: Elsevier/Academic Press, 2014. Print.| url=https://books.google.com/books?id=IloXAwAAQBAJ&pg=PA43&lpg=PA43&dq=leptomeningeal+carcinomatosis+is+present+in+1-5%25+of+patients+with+solid+tumors,+5-15%25+of+patients+with+leukemia,+and+1-2%25+of+patients+with+primary+brain+tumors.&source=bl&ots=ehEaDBCT5f&sig=vvSxdxDjNMBe0CdCP6fEcMaYJqU&hl=en&sa=X&ved=0ahUKEwi2ueuw37bKAhUG8j4KHWUUCoIQ6AEILTAC#v=onepage&q=leptomeningeal%20carcinomatosis%20is%20present%20in%201-5%25%20of%20patients%20with%20solid%20tumors%2C%205-15%25%20of%20patients%20with%20leukemia%2C%20and%201-2%25%20of%20patients%20with%20primary%20brain%20tumors.&f=false. Accessed on January 19, 2016
↑ “Neoplastic Meningitis”.

Template:WikiDoc Sources

[GleissnerChamberlain2006-1] 1.0 ^1.1 Gleissner, Beate; Chamberlain, Marc Charles (2006). “Neoplastic meningitis”. The Lancet Neurology. 5 (5): 443–452. doi:10.1016/S1474-4422(06)70443-4. ISSN 1474-4422.

[epidemiologynm2-2] 2.0 ^2.1 Hayat, M. A. Brain metastases from primary tumors : epidemiology, biology, and therapy. London: Elsevier/Academic Press, 2014. Print.| url=https://books.google.com/books?id=IloXAwAAQBAJ&pg=PA43&lpg=PA43&dq=leptomeningeal+carcinomatosis+is+present+in+1-5%25+of+patients+with+solid+tumors,+5-15%25+of+patients+with+leukemia,+and+1-2%25+of+patients+with+primary+brain+tumors.&source=bl&ots=ehEaDBCT5f&sig=vvSxdxDjNMBe0CdCP6fEcMaYJqU&hl=en&sa=X&ved=0ahUKEwi2ueuw37bKAhUG8j4KHWUUCoIQ6AEILTAC#v=onepage&q=leptomeningeal%20carcinomatosis%20is%20present%20in%201-5%25%20of%20patients%20with%20solid%20tumors%2C%205-15%25%20of%20patients%20with%20leukemia%2C%20and%201-2%25%20of%20patients%20with%20primary%20brain%20tumors.&f=false. Accessed on January 19, 2016

[3] “Neoplastic Meningitis”.

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