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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Neoplastic meningitis epidemiology and demographics

Introduction

Overview

Overview

Neoplastic meningitis occurs in approximately 3000-5000 of 100,000 patients with solid tumors, 5000-15,000 of 100,000 patients with leukemia, and 1000-2000 of 100,000 patients with primary brain tumors.[1][2]

Epidemiology and Demographics

Epidemiology and Demographics

Incidence

  • Neoplastic meningitis occurs in approximately 3000-5000 of 100,000 patients with solid tumors.
  • Neoplastic meningitis occurs in approximately 5000-15,000 of 100,000 patients with leukemia.
  • Neoplastic meningitis occurs in approximately 1000-2000 of 100,000 patients with primary brain tumors.[1][2]

Prevalence

  • Observational studies show that neoplastic meningitis develop in 1-5% of solid tumors, of which adenocarcinoma is the most frequently observed histology.
  • Neoplastic meningitis typically develop in the setting of an advanced stage and widely disseminated cancer in 70% of the cases. It can also present during the patients disease-free interval or remission in 20% of the time, and even be the first manifestation of cancer (5-10%) occasionally.[3]

Age

  • Neoplastic meningitis occurs more in elderly people, as it is associated with other primary cancer development.
References

References

  1. ↑ 1.0 1.1 Gleissner, Beate; Chamberlain, Marc Charles (2006). “Neoplastic meningitis”. The Lancet Neurology. 5 (5): 443–452. doi:10.1016/S1474-4422(06)70443-4. ISSN 1474-4422.
  2. ↑ 2.0 2.1 Hayat, M. A. Brain metastases from primary tumors : epidemiology, biology, and therapy. London: Elsevier/Academic Press, 2014. Print.| url=https://books.google.com/books?id=IloXAwAAQBAJ&pg=PA43&lpg=PA43&dq=leptomeningeal+carcinomatosis+is+present+in+1-5%25+of+patients+with+solid+tumors,+5-15%25+of+patients+with+leukemia,+and+1-2%25+of+patients+with+primary+brain+tumors.&source=bl&ots=ehEaDBCT5f&sig=vvSxdxDjNMBe0CdCP6fEcMaYJqU&hl=en&sa=X&ved=0ahUKEwi2ueuw37bKAhUG8j4KHWUUCoIQ6AEILTAC#v=onepage&q=leptomeningeal%20carcinomatosis%20is%20present%20in%201-5%25%20of%20patients%20with%20solid%20tumors%2C%205-15%25%20of%20patients%20with%20leukemia%2C%20and%201-2%25%20of%20patients%20with%20primary%20brain%20tumors.&f=false. Accessed on January 19, 2016
  3. ↑ “Neoplastic Meningitis”.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]