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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Neoplastic meningitis laboratory tests

Introduction

Overview

Overview

The proposed algorithm for the diagnosis of neoplastic meningitis include the following:[1]

Laboratory Findings

Laboratory Findings

Laboratory findings consistent with the diagnosis of neoplastic meningitis include:[2][3]

CSF analysis

  • Neoplastic meningitis is multifocal and cerebrospinal fluid at a particular site may show no abnormalities, if the pathological site is far away. Only 50% of those suspected with neoplastic meningitis are actually diagnosed and only the presence of malignant cells in the CSF is diagnostic.[2]
  • The criteria for CSF abnormalities that are consistent with the diagnosis of neoplastic meningitis include:[2]
  • Increased opening pressure (> 200mm of H2O)
  • Increased Leukocytes (>4/mm3)
  • Elevated protein (>50 mg/dL)
  • Decreased glucose (<60 mg/dL)
  • Positive tumor markers in CSF
  • These markers can be good indirect indicators of n eoplastic meningitis, but most are not sensitive enough to improve cytological diagnosis.
  • CSF cytology (gold standard)
  • Malignant cells, if present, are diagnostic
  • CSF cytology is estimated to have >95% specificity for neoplastic meningitis
References

References

  1. ↑ Berzero, Giulia; Diamanti, Luca; Di Stefano, Anna Luisa; Bini, Paola; Franciotta, Diego; Imarisio, Ilaria; Pedrazzoli, Paolo; Magrassi, Lorenzo; Morbini, Patrizia; Farina, Lisa Maria; Bastianello, Stefano; Ceroni, Mauro; Marchioni, Enrico (2015). “Meningeal Melanomatosis: A Challenge for Timely Diagnosis”. BioMed Research International. 2015: 1–6. doi:10.1155/2015/948497. ISSN 2314-6133.
  2. ↑ 2.0 2.1 2.2 Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016
  3. ↑ Ahn, Shin; Lim, Kyung Soo (2013). “Three Cases of Neoplastic Meningitis Initially Diagnosed with Infectious Meningitis in Emergency Department”. Case Reports in Emergency Medicine. 2013: 1–4. doi:10.1155/2013/561475. ISSN 2090-648X.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]