Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Nephrogenic diabetes insipidus history and symptoms
Introduction
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Overview
Overview
History
History
Symptoms
Symptoms
Nephrogenic diabetes inspidus (NDI) is suspected in individuals with:
- Polyuria (excessive urine production)
- Polydipsia (excessive thirst)
In children,
- Vomiting
- Gagging or retching
- Poor feeding
- Constipation or diarrhea
- Failure to thrive
- Unexplained fevers
- Lethargy or irritability
Symptoms common to children and elderly are:
- Dehydration associated with hot environment, water deprivation, diarrhea or fever
- Seizures with rapid increase or decrease in serum osmolarity
In patients with partial NDI,
- Tend to be diagnosed in later childhood
- Usually do not have growth or developmental delay and are able to concentrate the urine in response to dehydration or DDAVP administration, but to a lesser extent than unaffected individuals.
Heterozygotes for X-linked NDI, may have no symptoms or variable degree of polyuria or polydipsia or may be as severely affected as males. In females heterozygous for AVPR2 mutations, a correlation between urine-concentrating ability (and symptoms) and skewed X-chromosome inactivation in leukocytes has been reported in one family [Nomura et al 1997, Kinoshita et al. 2004].
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor in Chief: Cafer Zorkun, M.D., Ph.D. [2]