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Neuroblastoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

Overview

International neuroblastoma pathology classification system is used for the classification of neuroblastic tumors. It is subdivided in 02 main categories based on the morphologic features of neuroblastic tumors into; schwannian stroma-poor and schwannian stroma-rich/dominant.

Classification

Classification

  • International neuroblastoma pathology classification, a system based on the framework of Shimada classification with minor modifications is proposed for international use in classification of neuroblastic tumors. [1][2][3]
  • It is a biologically relevant and pathologically significant classification system based on the morphologic features of neuroblastic tumors,i-e,neuroblastoma, ganglioneuroblastoma and ganglioneuroma.[4][5]


 
 
 
Neuroblastic tumors
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Schwannian stroma-poor group
 
Schwannian stroma-rich/dominant group
 
 
 
 
 
 
 
Undifferentiated neuroblastoma
Poorly differentiated neuroblastoma
Differentiating neuroblastoma
 
Nodular ganglioneuroblastoma
Intermixed ganglioneuroblastoma
Maturing ganglioneuroma
Mature ganglioneuroma
 
 
 
 
 
 


References

References

  1. Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma. Stanford Medicine Surgical Pathology Criteria(2015) http://surgpathcriteria.stanford.edu/srbc/neuroblastoma-ganglioneuroblastoma-ganglioneuroma/ Accessed on October, 5 2015
  2. Shimada H, Umehara S, Monobe Y, Hachitanda Y, Nakagawa A, Goto S; et al. (2001). “International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children’s Cancer Group”. Cancer. 92 (9): 2451–61. PMID 11745303.
  3. Shimada, Hiroyuki; Ambros, Inge M.; Dehner, Louis P.; Hata, Jun-ichi; Joshi, Vijay V.; Roald, Borghild; Stram, Daniel O.; Gerbing, Robert B.; Lukens, John N.; Matthay, Katherine K.; Castleberry, Robert P. (1999). “The International Neuroblastoma Pathology Classification (the Shimada system)”. Cancer. 86 (2): 364–372. doi:10.1002/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7. ISSN 0008-543X.
  4. H. Shimada, I. M. Ambros, L. P. Dehner, J. Hata, V. V. Joshi, B. Roald, D. O. Stram, R. B. Gerbing, J. N. Lukens, K. K. Matthay & R. P. Castleberry (1999). “The International Neuroblastoma Pathology Classification (the Shimada system)”. Cancer. 86 (2): 364–372. PMID 10421273. Unknown parameter |month= ignored (help)
  5. H. Shimada, I. M. Ambros, L. P. Dehner, J. Hata, V. V. Joshi & B. Roald (1999). “Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee”. Cancer. 86 (2): 349–363. PMID 10421272. Unknown parameter |month= ignored (help)


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