Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Neurofibroma diagnostic criteria
Introduction
Overview
Overview
Diagnostic criteria
Diagnostic criteria
Following is the general diagnostic criteria for neurofibroma:
- Randomly oriented thin spindled cells with wavy, hyperchromatic nuclei
- Cellularity and organization are generally insufficient to produce palisading
- Thin processes with indistinct cytoplasm
- Most nuclei are small and bland
- Generally hypocellular
- Thin and thick collagen strands (“shredded carrot collagen”)
- Variable myxoid material surrounding cells and collagen
- Occasional mast cells and lymphocytes, rare foam cells
- Diffusely S100 immunoreactive
- Entrapped axons of overrun nerve frequently scattered within lesion
- Nerve frequently not grossly identifiable
- May show localized hyperchromatic atypical cells (“ancient change”)
- Localized cells with large, pleomorphic nuclei, cytoplasmic intranuclear inclusions, smudgy chromatin, and inconspicuous nucleoli
- Often large, long standing lesions
- Low mitotic index
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]