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Neuropeptide B
Introduction
Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[1][2] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.
References
References
- ↑ Singh G, Davenport AP (Aug 2006). “Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system”. British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
- ↑ Hondo M, Ishii M, Sakurai T (2008). “The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion”. Results and problems in cell differentiation. 46: 239–56. doi:10.1007/400_2007_056. PMID 18204824.