Neurosyphilis risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The most potent risk factor in the development of neurosyphilis is HIV infection. Other risk factors include male gender, high serum RPR titer, advanced age, and African American race.

Risk Factors

The most potent risk factor in the development of neurosyphilis is HIV infection. Other risk factors include male gender, high serum RPR titer, advanced age, and African American race.

Common Risk Factors

Common risk factors in the development of neurosyphilis include:^[1]^[2]

HIV infection
Male gender
High serum rapid plasma reagent titer

Less Common Risk Factors

Less common risk factors in the development of neurosyphilis include:^[2]

Advanced age
African American race

References

↑ Vidal-Bermúdez JE, Bonasser-Filho F, Schiavon-Nogueira R (2004). “[Syphilitic meningomyelitis in a patient with AIDS]”. Rev Neurol. 38 (10): 998–9. PMID 15175987.
↑ ^2.0 ^2.1 Shi M, Peng RR, Gao Z, Zhang S, Lu H, Guan Z; et al. (2016). “Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention”. J Eur Acad Dermatol Venereol. 30 (4): 659–66. doi:10.1111/jdv.13514. PMID 26660338.

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[pmid15175987-1] Vidal-Bermúdez JE, Bonasser-Filho F, Schiavon-Nogueira R (2004). “[Syphilitic meningomyelitis in a patient with AIDS]”. Rev Neurol. 38 (10): 998–9. PMID 15175987.

[pmid26660338-2] 2.0 ^2.1 Shi M, Peng RR, Gao Z, Zhang S, Lu H, Guan Z; et al. (2016). “Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention”. J Eur Acad Dermatol Venereol. 30 (4): 659–66. doi:10.1111/jdv.13514. PMID 26660338.

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