Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Neutropenia pathophysiology
Introduction
Overview
Overview
Neutropenia may develop as a result of one of the three mechanisms: impaired granulocyte production, margination, and peripheral destruction. Genes involved in the pathogenesis of neutropenia include ELA2, HAX1, and CXCR4.
Pathophysiology
Pathophysiology
Pathogenesis
Neutropenia may develop as a result of one of the three mechanisms:[1]
- Impaired granulocyte production
- Hematologic malignancy with bone marrow infiltration
- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow
- Nutritional deficiencies
- Margination (process where free flowing blood cells exit circulation)
- Splenic sequestration
- Adherence to the vascular endothelium
- Peripheral destruction
- Autoimmune hemolysis
- Drug-induced hemolysis
Genetics
Genes involved in the pathogenesis of neutropenia include ELA2, HAX1, and CXCR4.
References
References
- ↑ Schwartzberg LS. (2006). “Neutropenia: etiology and pathogenesis”. Clin Cornerstone. 8 (5): 5–11. Text “pmid 17379162” ignored (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Daniel A. Gerber, M.D. [2]