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Nigericin
Introduction
Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called
Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464.
Nigericin acts as an H+, K+, Pb++ ionophore. It most commonly is an antiporter of H+ and K+.
In the past Nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions. Nigericin exhibits anti-HIV activity.
Properties
Properties
- CAS number: 28643-80-3
- Merck index: 12, 6633
- Molecular weight: 747
- Formula C40H67O11Na
The properties are copied from a manufacturer’s Nigericin product page]