Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Noncompaction cardiomyopathy medical therapy
Introduction
Overview
Overview
The medical management of noncompaction cardiomyopathy is similar to that of other cardiomyopathies and includes the use of ACE inhibitors, beta blockers and aspirin[1].
Antiplatelet Therapy
Antiplatelet Therapy
Given the risk of embolization, all patients with NCC are generally treated with prophylactic aspirin.
Beta Blockade
Beta Blockade
Noncompaction cardiomyopathy is assocatiated with an increased risk of arrhythmias including ventricular tachyarrhythmias. Beta blockade may reduce this risk. The impact of Carvedilol on left ventricular function has been reported [2].
Angiotensin Converting Enzyme (ACE) Inhibition
Angiotensin Converting Enzyme (ACE) Inhibition
Similar to other cardiomyopathies, ACE inhibitors are indicated given the low cardiac output in these patients.
Calcium Channel Blockade
Calcium Channel Blockade
Calcium channel blockers may be of benefit in those patients with apical hypertrophy and no reduction in systolic contractility.
Patients with Mitochondrial Abnormalities
Patients with Mitochondrial Abnormalities
Some groups have recommended the use of Coenzyme Q10, riboflavin, thiamine and carnitine in these patients.
References
References
- ↑ Botto, LD. Left ventricular noncompaction. Orphanet encyclopedia. http://www.orpha.net/data/patho/GB/uk-LVNC.pdf
- ↑ Toyono M, Kondo C, Nakajima Y, et al. Effects of carvedilol on left ventricular function, mass, and scintigraphic findings in isolated left ventricular non-compaction. Heart. 2001; 86: e4–e6.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]