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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Noonan syndrome ECG findings

Introduction

Overview

Overview

The most common findings on ECG in patients with Noonan syndrome are left-axis deviation and abnormal R/S ratio in the left precordial leads.

ECG Findings

ECG Findings

Electrocardiograms in patients with Noonan syndrome often show a combination of the following: left-axis deviation, abnormal R/S ratio in the left precordial leads, wide QRS complexes, inverted T waves in lead III and V1-V3, and giant Q waves.[1][2] ECG findings are often not related to detectable structural abnormalities of heart and chest wall and may be present independently of established heart disease.[3] Other findings may include sinus bradycardia, RBBB, and other signs of right and left ventricular overload depending on the phenotypic presentation of the disease.[4]

References

References

  1. ↑ Sanchez-Cascos A (1983). “The Noonan syndrome”. Eur Heart J. 4 (4): 223–9. PMID 6884370.
  2. ↑ Raaijmakers R, Noordam C, Noonan JA, Croonen EA, van der Burgt CJ, Draaisma JM (2008). “Are ECG abnormalities in Noonan syndrome characteristic for the syndrome?”. Eur J Pediatr. 167 (12): 1363–7. doi:10.1007/s00431-008-0670-9. PMID 18270737.
  3. ↑ Roberts AE, Allanson JE, Tartaglia M, Gelb BD (2013). “Noonan syndrome”. Lancet. 381 (9863): 333–42. doi:10.1016/S0140-6736(12)61023-X. PMID 23312968.
  4. ↑ Bertola DR, Kim CA, Sugayama SM, Albano LM, Wagenführ J, Moysés RL; et al. (2000). “Cardiac findings in 31 patients with Noonan’s syndrome”. Arq Bras Cardiol. 75 (5): 409–12. PMID 11080752.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Serge Korjian, Yazan Daaboul