ONECUT1
One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [1]
Function
Function
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
Further reading
Further reading
- Rausa FM, Tan Y, Costa RH (2003). “Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding”. Mol. Cell. Biol. 23 (2): 437–49. doi:10.1128/mcb.23.2.437-449.2003. PMC 151533. PMID 12509444.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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