Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ONECUT1
Introduction
One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [1]
Function
Function
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
Further reading
Further reading
- Rausa FM, Tan Y, Costa RH (2003). “Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding”. Mol. Cell. Biol. 23 (2): 437–49. doi:10.1128/mcb.23.2.437-449.2003. PMC 151533. PMID 12509444.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.