OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.^[1]

OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. OTUD6B, also known as DUBA5, belongs to a DUB subfamily characterized by an ovarian tumor domain (OTU).^[1] OTUD6B function may be connected to growth and proliferation.^[2][3] This hypothesis is supported by a recent study indicating that OTUD6B knock out mice, obtained through exon 4 deletion, are subviable and smaller in size.^[4] In humans, OTUD6B mutations have been connected to an intellectual disability syndrome associated with dysmorphic features.^[4]

Previous studies on model organisms (see below) cannot be verified by this editor.

Model organisms have been used in the study of OTUD6B function. A conditional knockout mouse line, called Otud6b^{tm1a(EUCOMM)Wtsi[9][10]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[7][14] Twenty five tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.^[7]