Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Optic nerve glioma causes
Introduction
Overview
Overview
There is no established cause for optic nerve glioma.
Causes
Causes
- There is no established cause for optic nerve glioma.
- Sporadic pilocytic astrocytomas usually have a tandem duplication of chromosome 7q34 and associated BRAF-KIAA fusion gene.[1][2] Pilocytic astrocytomas associated with neurofibromatosis type 1 lack this fusion gene. However, it is unknown if the mutation in the BRAF-KIAA fusion gene in the setting of optic nerve glioma is the primary cause of the disease as it is in other pilocystic astrocytomas.
References
References
- ↑ Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A; et al. (2009). “Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours”. Br J Cancer. 101 (4): 722–33. doi:10.1038/sj.bjc.6605179. PMC 2736806. PMID 19603027.
- ↑ Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA; et al. (2009). “Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma”. Neurology. 73 (19): 1526–31. doi:10.1212/WNL.0b013e3181c0664a. PMC 2777068. PMID 19794125.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]