Common physical examination findings of optic nerve glioma include nystagmus, strabismus, proptosis, visual impairment, afferent pupillary defect, edema and/or pallor of optic disc, torticollis and deficits of cranial nerve II.

• Nystagmus may be present.^[1][2]
• Strabismus
• Visual impairment
• Proptosis
• Visual field tests
• Afferent pupillary defect
• Fundoscopic examination may show pallor and/or edema of the optic disc due to atrophy. Initially, optic nerve head is swollen but subsequently it becomes atrophic. Central retinal vein occlusion and optociliary collaterals may occasionally be seen.
• On slit-lamp examination iris hamartomas (Lisch nodules) may be identified in optic nerve glioma patients with associated NF-1.

• Torticollis may be present^[3]

• Mental status may be altered if obstructive hydrocephalus is present.
• There are deficits in cranial nerves II- Involuntary eyeball movement and loss of peripheral vision in one or both eyes.

• Café-au-lait spots or hyperpigmented macules may be present in patients with optic pathway glioma associated with NF-1.
• Axillary or inguinal freckles may be present in patients with optic nerve glioma associated with NF-1.