Osteogenesis imperfecta X-ray

• Sine qua non of OI is generalized osteoporosis of both the axial and appendicular skeleton.
• Milder forms of OI result in thin, overtubulated bones with thin cortices, and relatively few fractures. The short tubular bones are also affected, though they are less frequently fractured.
• More severe forms of OI, such as in types II and III, feature thickened, shortened long bones with multiple fractures; these forms are often complicated by hyperplastic callus formation.
• Radiographs of the skull may reveal normal skull development in milder forms of disease. With increasing disease severity, the skull demonstrates poor mineralization and multiple wormian, or intrasutural, bones.
• The chest may be small. Multiple rib fractures are often found; these can cause the ribs to become broad and deformed.
• Spinal abnormalities in all subtypes include basilar invagination, platyspondyly, and scoliosis.

Patient #1

Patient#2

Template:WikiDoc Sources