Osteosarcoma biopsy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Biopsy of osteosarcoma is important for confirming the diagnosis and the determining histologic subtype. Biopsy may be performed percutaneously with either a fine-needle, or wide-bore needle, or through a formal incision.

Biopsy

Biopsy of osteosarcoma is important for confirming the diagnosis and the determining histologic subtype.
Biopsy procedures include:^[1]^[2]^[3]^[4]
- Needle biopsy
  - Percutaneously with either a fine-needle, or a wide-bore needle
- Surgical biopsy
  - Through a formal incision
More invasive methods carry a higher risk of complications and contamination of tissue planes.
Each year 30% of patients lose their limbs through inappropriate biopsy site and technique.
In principle, biopsies should be performed at a tumor center by a specialist in tumor surgery.
Inappropriate alignment of the biopsy or inadvertent contamination of soft tissues can render subsequent limb-preserving reconstructive surgery impossible.

References

↑ Moore DD, Luu HH (2014). “Osteosarcoma”. Cancer Treat. Res. 162: 65–92. doi:10.1007/978-3-319-07323-1_4. PMID 25070231.
↑ Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M (March 2010). “Clinical presentation and imaging of bone and soft-tissue sarcomas”. Cleve Clin J Med. 77 Suppl 1: S2–7. doi:10.3949/ccjm.77.s1.01. PMID 20179183.
↑ Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH (November 2010). “The prognosis for patients with osteosarcoma who have received prior manipulative therapy”. J Bone Joint Surg Br. 92 (11): 1580–5. doi:10.1302/0301-620X.92B11.24706. PMID 21037356.
↑ Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M (July 2018). “The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients”. BMC Med. Genet. 19 (1): 112. doi:10.1186/s12881-018-0627-4. PMC 6035436. PMID 29980176.

Overview