Osteosarcoma causes

There are no established exact causes for osteosarcoma. But physicians and medical researchers suggest that the the DNA mutations (either inherited or acquired after birth) inside the bone cellular system can be responsible for the occurrence of OS.

Common causes of osteosarcoma may include:

• There is limited understanding about the exact etiology of osteosarcoma.^{[1][2][3][4][5][6]}.

• The peak age during puberty seems to have an important relationship between rapid bone growth and the development and progression of OS.
• Commonly osteosarcoma occur at an earlier age in girls than boys.
• Osteosarcoma have also been associated with the previous history of radiation, the use of diagnostic radiocontrast agent s such as:
  • Intravenous radium 224
  • Thorotrast
  • Exposure to alkylating agents

Less common causes of osteosarcoma include:

• On the other hand, the conditions associated with an increased risk of development of osteosarcoma include:
  • Paget’s disease
  • Solitary or multiple osteochondroma
  • Solitary enchondroma or enchondromatosis (Ollier’s disease)
  • Multiple hereditary exostoses
  • Fibrous dysplasia
  • Chronic osteomyelitis
  • Sites of bone infractions and sites of metallic implants

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