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Otu deubiquitinase 5
Introduction
OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. [1]
Function
Function
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
Further reading
Further reading
- Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O’Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). “DUBA: a deubiquitinase that regulates type I interferon production”. Science. 318 (5856): 1628–32. doi:10.1126/science.1145918. PMID 17991829.
- Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). “Phosphorylation-dependent activity of the deubiquitinase DUBA”. Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969.
- Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). “OTUD5 regulates p53 stability by deubiquitinating p53”. PLoS ONE. 8 (10): e77682. doi:10.1371/journal.pone.0077682. PMCÂ 3797110. PMIDÂ 24143256.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.