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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Oxaflozane

Introduction

Overview

Overview

Oxaflozane (Conflictan) is an antidepressant and anxiolytic drug that was introduced in France in 1982 by Solvay for the treatment of depression, but has since been abandoned.[1][2] It is a prodrug to N-dealkyloxaflozane, which acts as a non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]

References

References

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 766. ISBN 3-88763-075-0.
  2. ↑ Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. p. 1122. ISBN 0-8155-1144-2.
  3. ↑ Leysen DC (February 1999). “Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal. 2 (2): 109–20. PMID 16160946.
  4. ↑ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). “Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology. 30 (1): 123–6. doi:10.3109/15563659208994452. PMID 1542141.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]