Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Oxyntomodulin
Introduction
Oxyntomodulin is a naturally occurring 37 amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite. A recent study has found that it can be used as a weight loss treatment.[1][2][3][4]
The mechanism of action of oxyntomodulin is not well understood. It is known to bind both the GLP-1 receptor and the glucagon receptor but it is not known whether the effects of the hormone are mediated through these receptors or through an unidentified receptor.
Thiakis [1], a biotechnology company based in London and founded by Professor Steve Bloom and Dr John Burt, is developing a novel analogue of oxyntomodulin for the treatment of obesity.
References
References
- ↑ Weight loss study Telegraph
- ↑ Scientists Discoover New Weapon Against Obesity-Oxytomodulin health.dailynewscentral.com
- ↑ BBC News story: New way to treat obesity heralded, April 26, 2006
- ↑ Wynne K, Park AJ, Small CJ; et al. (2006). “Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial”. International journal of obesity (2005). 30 (12): 1729–36. doi:10.1038/sj.ijo.0803344. PMID 16619056.
External links
External links
- Oxyntomodulin at the US National Library of Medicine Medical Subject Headings (MeSH)