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P27 (gene)
Introduction
Overview
Overview
p27 is a human gene on chromosome 6 and belongs to the cip/kip family. It encodes a cell cycle inhibitor protein that binds to cyclin D and CDK4 and causes arrest in G1 phase. p27 is activated by Transforming Growth Factor β (TGF β). [1] A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. [2]
References
References
- ↑ p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 Hideo Toyoshima, Tony Hunter; Cell, Vol 78, 67-74, 15 July 1994
- ↑ Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1 Cell Press. , Vol 85, 721-732, 31 May 1996