p57 (gene)

Overview

p57 or p57KIP2 is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. ^[1] Thus p57KIP2 causes arrest of the cell cycle in G1 phase. A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. ^[2]

References

↑ p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. GENES & DEVELOPMENT 9:650-662, 1995. ISSN 0890-9369.
↑ New p57KIP2 mutations in Beckwith-Wiedemann syndrome Human Genetics, Vol 100, Num 5-6 / Sept 1997.

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[1] 57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. GENES & DEVELOPMENT 9:650-662, 1995. ISSN 0890-9369.

[2] New p57KIP2 mutations in Beckwith-Wiedemann syndrome Human Genetics, Vol 100, Num 5-6 / Sept 1997.

[1]

[2]

p57 (gene)

Overview

References

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