Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
PHF2
Introduction
PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene. [1]
Function
Function
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
Further reading
Further reading
- Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). “Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma”. Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMCÂ 2633285. PMIDÂ 18990233.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.