
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions โ written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
PIN4
Introduction
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is an enzyme that in humans is encoded by the PIN4 gene.[1][2][3]
References
References
- โ Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). “Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation”. BMC Mol Biol. 7: 9. doi:10.1186/1471-2199-7-9. PMCย 1420321. PMIDย 16522211.
- โ Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). “The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae”. BMC Biol. 5: 37. doi:10.1186/1741-7007-5-37. PMCย 2031878. PMIDย 17875217.
- โ “Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)”.
Further reading
Further reading
- Uchida T, Fujimori F, Tradler T, et al. (1999). “Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase”. FEBS Lett. 446 (2โ3): 278โ82. doi:10.1016/S0014-5793(99)00239-2. PMIDย 10100858.
- Rulten S, Thorpe J, Kay J (1999). “Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases”. Biochem. Biophys. Res. Commun. 259 (3): 557โ62. doi:10.1006/bbrc.1999.0828. PMIDย 10364457.
- Sekerina E, Rahfeld JU, Mรผller J, et al. (2000). “NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein”. J. Mol. Biol. 301 (4): 1003โ17. doi:10.1006/jmbi.2000.4013. PMIDย 10966801.
- Terada T, Shirouzu M, Fukumori Y, et al. (2001). “Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14”. J. Mol. Biol. 305 (4): 917โ26. doi:10.1006/jmbi.2000.4293. PMIDย 11162102.
- Suzuki Y, Tsunoda T, Sese J, et al. (2001). “Identification and characterization of the potential promoter regions of 1031 kinds of human genes”. Genome Res. 11 (5): 677โ84. doi:10.1101/gr.gr-1640r. PMCย 311086. PMIDย 11337467.
- Fujiyama S, Yanagida M, Hayano T, et al. (2002). “Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes”. J. Biol. Chem. 277 (26): 23773โ80. doi:10.1074/jbc.M201181200. PMIDย 11960984.
- Surmacz TA, Bayer E, Rahfeld JU, et al. (2002). “The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding”. J. Mol. Biol. 321 (2): 235โ47. doi:10.1016/S0022-2836(02)00615-0. PMIDย 12144781.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899โ903. doi:10.1073/pnas.242603899. PMCย 139241. PMIDย 12477932.
- Reimer T, Weiwad M, Schierhorn A, et al. (2003). “Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14”. J. Mol. Biol. 330 (5): 955โ66. doi:10.1016/S0022-2836(03)00713-7. PMIDย 12860119.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121โ7. doi:10.1101/gr.2596504. PMCย 528928. PMIDย 15489334.
