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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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PLCB2

Introduction

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.[1][2][3]

Function

Function

The gene codes for the enzyme phospholipase C Ξ²2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

Interactions

PLCB2 has been shown to interact with MAP2K3[4] and TRPM7.[5]

References

References

  1. ↑ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). “Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2”. J. Biol. Chem. 267 (23): 16048–55. PMIDΒ 1644792.
  2. ↑ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). “Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization”. Cytogenet. Cell Genet. 83 (1–2): 48–9. doi:10.1159/000015166. PMIDΒ 9925923.
  3. ↑ “Entrez Gene: PLCB2 phospholipase C, beta 2”.
  4. ↑ Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). “Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3”. Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMIDΒ 12054652.
  5. ↑ Runnels LW, Yue L, Clapham DE (May 2002). “The TRPM7 channel is inactivated by PIP(2) hydrolysis”. Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMIDΒ 11941371.
Further reading

Further reading

  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). “Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway”. J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMCΒ 329852. PMIDΒ 1979339.
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). “Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line”. Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMIDΒ 7589147.
  • Buhl AM, Osawa S, Johnson GL (1995). “Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor”. J. Biol. Chem. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMIDΒ 7649993.
  • Chen P, Mayne M, Power C, Nath A (1997). “The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases”. J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMIDΒ 9278385.
  • DarΓ¨ E, Kifor O, Brown EM, Weber G (1998). “Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor”. J. Mol. Endocrinol. 21 (1): 7–17. doi:10.1677/jme.0.0210007. PMIDΒ 9723859.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). “HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease”. Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMIDΒ 9730685.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). “Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat”. J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMIDΒ 10501179.
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). “Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages”. J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMIDΒ 10843712.
  • Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000). “Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF”. J. Biol. Chem. 275 (48): 37559–64. doi:10.1074/jbc.M006635200. PMIDΒ 10980202.
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). “Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)”. Biochim. Biophys. Acta. 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMIDΒ 11118617.
  • Singer AU, Waldo GL, Harden TK, Sondek J (2002). “A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q”. Nat. Struct. Biol. 9 (1): 32–6. doi:10.1038/nsb731. PMIDΒ 11753430.
  • Runnels LW, Yue L, Clapham DE (2002). “The TRPM7 channel is inactivated by PIP(2) hydrolysis”. Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMIDΒ 11941371.
  • Scarlata S (2002). “Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts”. Biochemistry. 41 (22): 7092–9. doi:10.1021/bi025625j. PMIDΒ 12033943.
  • Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G, Capitani S (2002). “Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors”. J. Leukoc. Biol. 71 (6): 957–65. PMIDΒ 12050180.
  • Barr AJ, Marjoram R, Xu J, Snyderman R (2002). “Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3”. Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMIDΒ 12054652.
  • Buck E, Schatz P, Scarlata S, Iyengar R (2002). “Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2”. J. Biol. Chem. 277 (51): 49707–15. doi:10.1074/jbc.M205553200. PMIDΒ 12388553.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). “Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha”. Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMIDΒ 12482669.