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PLIN

Introduction

Perilipin, also known as PLIN, is a human gene.[1]

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis.[1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: PLIN perilipin”.
Further reading

Further reading

  • Tai ES, Ordovas JM (2007). “The role of perilipin in human obesity and insulin resistance”. Curr. Opin. Lipidol. 18 (2): 152–6. doi:10.1097/MOL.0b013e328086aeab. PMID 17353663.
  • Nishiu J, Tanaka T, Nakamura Y (1998). “Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method”. Genomics. 48 (2): 254–7. doi:10.1006/geno.1997.5179. PMID 9521880.
  • Souza SC, Muliro KV, Liscum L; et al. (2002). “Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system”. J. Biol. Chem. 277 (10): 8267–72. doi:10.1074/jbc.M108329200. PMID 11751901.
  • Hagström-Toft E, Qvisth V, Nennesmo I; et al. (2002). “Marked heterogeneity of human skeletal muscle lipolysis at rest”. Diabetes. 51 (12): 3376–83. PMID 12453889.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Mottagui-Tabar S, Rydén M, Löfgren P; et al. (2004). “Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis”. Diabetologia. 46 (6): 789–97. doi:10.1007/s00125-003-1112-x. PMID 12802495.
  • Wang Y, Sullivan S, Trujillo M; et al. (2004). “Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot”. Obes. Res. 11 (8): 930–6. PMID 12917496.
  • Zhang HH, Souza SC, Muliro KV; et al. (2004). “Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis”. J. Biol. Chem. 278 (51): 51535–42. doi:10.1074/jbc.M309591200. PMID 14527948.
  • Kern PA, Di Gregorio G, Lu T; et al. (2004). “Perilipin expression in human adipose tissue is elevated with obesity”. J. Clin. Endocrinol. Metab. 89 (3): 1352–8. PMID 15001633.
  • Arvidsson E, Blomqvist L, Rydén M (2004). “Depot-specific differences in perilipin mRNA but not protein expression in obesity”. J. Intern. Med. 255 (5): 595–601. doi:10.1111/j.1365-2796.2004.01314.x. PMID 15078502.
  • Dalen KT, Schoonjans K, Ulven SM; et al. (2004). “Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma”. Diabetes. 53 (5): 1243–52. PMID 15111493.
  • Qi L, Corella D, Sorlí JV; et al. (2005). “Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women”. Clin. Genet. 66 (4): 299–310. doi:10.1111/j.1399-0004.2004.00309.x. PMID 15355432.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Yan W, Chen S, Huang J; et al. (2005). “Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese”. Obes. Res. 12 (11): 1733–7. PMID 15601966.
  • Qi L, Shen H, Larson I; et al. (2005). “Gender-specific association of a perilipin gene haplotype with obesity risk in a white population”. Obes. Res. 12 (11): 1758–65. PMID 15601970.
  • Qi L, Tai ES, Tan CE; et al. (2005). “Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population”. J. Mol. Med. 83 (6): 448–56. doi:10.1007/s00109-004-0630-4. PMID 15770500.
  • Forcheron F, Legedz L, Chinetti G; et al. (2005). “Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression”. Arterioscler. Thromb. Vasc. Biol. 25 (8): 1711–7. doi:10.1161/01.ATV.0000174123.19103.52. PMID 15961705.
  • Corella D, Qi L, Sorlí JV; et al. (2005). “Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction”. J. Clin. Endocrinol. Metab. 90 (9): 5121–6. doi:10.1210/jc.2005-0576. PMID 15985482.
  • Moore HP, Silver RB, Mottillo EP; et al. (2006). “Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase”. J. Biol. Chem. 280 (52): 43109–20. doi:10.1074/jbc.M506336200. PMID 16243839.
  • Shimizu M, Akter MH, Emi Y; et al. (2007). “Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair”. J. Biochem. 139 (3): 563–73. doi:10.1093/jb/mvj053. PMID 16567422.

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