POEMS syndrome causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis.

Causes

There are no known and well established causes of POEMS syndrome.
Some studies suggest that marked activation of the pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) play a role in the disease pathogenesis.^[1]
Weak or even decreased (TGF beta 1) antagonistic reaction insufficient to counteract the noxious effects of cytokines can also result in this syndrome.^[1]

References

↑ ^1.0 ^1.1 Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ (February 1996). “Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome”. Blood. 87 (4): 1458–65. PMID 8608236.

Overview