Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
POEMS syndrome diagnostic criteria
Introduction
Overview
Overview
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of polyneuropathy and a monoclonal plasma cell proliferative disorder. Major criteria include presence of sclerotic bone lesions or mixed sclerotic/lytic lesions, presence of Castleman’s disease and elevated serum VEGF levels. Minor criteria include presence of organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis and polycythemia.
Diagnostic Criteria
Diagnostic Criteria
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, at least one major and at least one minor criteria are fulfilled. The following table enlists the mandatory, major and minor criteria required for the diagnosis of POEMS syndrome:_International_Myeloma_Working_Group_(IMWG)_Criteria_for_the_Diagnosis_of_Multiple_Myeloma-1|[1]
| Mandatory Criteria | Major Criteria | Minor Criteria |
|---|---|---|
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]