Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
POEMS syndrome laboratory findings
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of POEMS syndrome include increased serum VEGF level, increased number of thrombocytes, increased number of erythrocytes, elevated cerebrospinal fluid (CSF) protein content, increased number of leukocytes, low levels of IgG lambda or IgA lambda M-protein in the serum, and increased number of plasma cells in the bone marrow.
Laboratory Findings
Laboratory Findings
Laboratory findings consistent with the diagnosis of POEMS syndrome include:
- Increased number of thrombocytes[1][2][3]
- Increased number of erythrocytes[1][2][3]
- Elevated cerebrospinal fluid (CSF) protein content[2]
- Increased number of leukocytes[3]
- Low levels of IgG lambda or IgA lambda M-protein in the serum[3]
- Increased number of plasma cells in the bone marrow[3]
- Increased serum VEGF level[4]
- Elevated levels of antitiroglobulin antibody and antithyroid peroxydase antibody[5]
References
References
- ↑ 1.0 1.1 Nozza A (2017). “POEMS SYNDROME: an Update”. Mediterr J Hematol Infect Dis. 9 (1): e2017051. doi:10.4084/MJHID.2017.051. PMC 5584767. PMID 28894560.
- ↑ 2.0 2.1 2.2 Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL (July 1980). “Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature”. Medicine (Baltimore). 59 (4): 311–22. PMID 6248720.
- ↑ 3.0 3.1 3.2 3.3 3.4 Takatsuki K, Sanada I (September 1983). “Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases”. Jpn. J. Clin. Oncol. 13 (3): 543–55. PMID 6315993.
- ↑ Nobile-Orazio E, Terenghi F, Giannotta C, Gallia F, Nozza A (March 2009). “Serum VEGF levels in POEMS syndrome and in immune-mediated neuropathies”. Neurology. 72 (11): 1024–6. doi:10.1212/01.wnl.0000344569.13496.ff. PMID 19289745.
- ↑ GüneÅŸ HN, BilecenoÄŸlu NT, Åžener U, YoldaÅŸ TK (April 2015). “POEMS syndrome with peripheral and central nervous system demyelination: case report”. Neurologist. 19 (4): 101–3. doi:10.1097/NRL.0000000000000017. PMID 25888197.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]