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PPM1B
Introduction
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.[1][2]
Function
Function
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.[2]
References
References
- β Marley AE, Kline A, Crabtree G, Sullivan JE, Beri RK (August 1998). “The cloning expression and tissue distribution of human PP2Cbeta”. FEBS Lett. 431 (1): 121β4. doi:10.1016/S0014-5793(98)00708-X. PMIDΒ 9684878.
- β 2.0 2.1 “Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform”.
- β 3.0 3.1 Cheng A, Kaldis P, Solomon MJ (November 2000). “Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms”. J. Biol. Chem. 275 (44): 34744β9. doi:10.1074/jbc.M006210200. PMIDΒ 10934208.
- β 4.0 4.1 4.2 Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (January 2004). “Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity”. J. Biol. Chem. 279 (3): 1739β46. doi:10.1074/jbc.M306273200. PMIDΒ 14585847.
- β Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S (February 2001). “Regulation of the TAK1 signaling pathway by protein phosphatase 2C”. J. Biol. Chem. 276 (8): 5753β9. doi:10.1074/jbc.M007773200. PMIDΒ 11104763.
- β Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E. “The serine/threonine phosphatase PPM1B (PP2CΞ²) selectively modulates PPARΞ³ activity”. Biochem. J. 451 (1): 45β53. doi:10.1042/BJ20121113. PMIDΒ 23320500.
Further reading
Further reading
- Hishiya A, Ohnishi M, Tamura S, Nakamura F (1999). “Protein phosphatase 2C inactivates F-actin binding of human platelet moesin”. J. Biol. Chem. 274 (38): 26705β12. doi:10.1074/jbc.274.38.26705. PMIDΒ 10480873.
- Cheng A, Ross KE, Kaldis P, Solomon MJ (2000). “Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases”. Genes Dev. 13 (22): 2946β57. doi:10.1101/gad.13.22.2946. PMCΒ 317162. PMIDΒ 10580002.
- Cheng A, Kaldis P, Solomon MJ (2000). “Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms”. J. Biol. Chem. 275 (44): 34744β9. doi:10.1074/jbc.M006210200. PMIDΒ 10934208.
- Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S (2001). “Regulation of the TAK1 signaling pathway by protein phosphatase 2C”. J. Biol. Chem. 276 (8): 5753β9. doi:10.1074/jbc.M007773200. PMIDΒ 11104763.
- Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (2001). “A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease”. Am. J. Hum. Genet. 69 (4): 869β75. doi:10.1086/323624. PMCΒ 1226072. PMIDΒ 11524703.
- Seroussi E, Shani N, Ben-Meir D, Chajut A, Divinski I, Faier S, Gery S, Karby S, Kariv-Inbal Z, Sella O, Smorodinsky NI, Lavi S (2001). “Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta”. J. Mol. Biol. 312 (3): 439β51. doi:10.1006/jmbi.2001.4967. PMIDΒ 11563908.
- Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (2004). “Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity”. J. Biol. Chem. 279 (3): 1739β46. doi:10.1074/jbc.M306273200. PMIDΒ 14585847.
- Parvari R, Gonen Y, Alshafee I, Buriakovsky S, Regev K, Hershkovitz E (2005). “The 2p21 deletion syndrome: characterization of the transcription content”. Genomics. 86 (2): 195β211. doi:10.1016/j.ygeno.2005.04.001. PMIDΒ 15913950.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173β8. doi:10.1038/nature04209. PMIDΒ 16189514.