Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
PRPF6
Introduction
Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[1][2][3]
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]
Interactions
Interactions
PRPF6 has been shown to interact with TXNL4B,[4] ARAF[5][6] and Androgen receptor.[7]
References
References
- ↑ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). “A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors”. Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.
- ↑ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). “The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions”. J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
- ↑ 3.0 3.1 “Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)”.
- ↑ Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). “DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression”. J. Biol. Chem. United States. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
- ↑ Yuryev, Anton; Wennogle Lawrence P (February 2003). “Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis”. Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
- ↑ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). “Isoform-specific localization of A-RAF in mitochondria”. Mol. Cell. Biol. UNITED STATES. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.
- ↑ Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). “Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor”. J. Biol. Chem. United States. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.
Further reading
Further reading
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Yuryev A, Ono M, Goff SA, et al. (2000). “Isoform-specific localization of A-RAF in mitochondria”. Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). “The DNA sequence and comparative analysis of human chromosome 20”. Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis”. RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
- Zhao Y, Goto K, Saitoh M, et al. (2002). “Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor”. J. Biol. Chem. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. PMID 12039962.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yuryev A, Wennogle LP (2003). “Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis”. Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Goto K, Zhao Y, Saito M, et al. (2003). “Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments”. J. Steroid Biochem. Mol. Biol. 85 (2–5): 201–8. doi:10.1016/S0960-0760(03)00196-1. PMID 12943705.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Will CL, Schneider C, Hossbach M, et al. (2004). “The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome”. RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
- Sun X, Zhang H, Wang D, et al. (2004). “DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression”. J. Biol. Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions”. Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Laggerbauer B, Liu S, Makarov E, et al. (2005). “The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation”. RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
- Batsché E, Yaniv M, Muchardt C (2006). “The human SWI/SNF subunit Brm is a regulator of alternative splicing”. Nat. Struct. Mol. Biol. 13 (1): 22–9. doi:10.1038/nsmb1030. PMID 16341228.
- Fan S, Goto K, Chen G, et al. (2006). “Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor”. Biochem. Biophys. Res. Commun. 341 (1): 192–201. doi:10.1016/j.bbrc.2005.12.167. PMID 16414017.
- Ewing RM, Chu P, Elisma F, et al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMCÂ 1847948. PMIDÂ 17353931.