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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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PSMA6

Introduction

Proteasome (prosome, macropain) subunit, alpha type, 6, also known as PSMA6, is a human gene.[1]

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.[1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6”.
Further reading

Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). “Structure and functions of the 20S and 26S proteasomes”. Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
  • Goff SP (2003). “Death by deamination: a novel host restriction system for HIV-1”. Cell. 114 (3): 281–3. PMID 12914693.
  • DeMartino GN, Orth K, McCullough ML; et al. (1991). “The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous”. Biochim. Biophys. Acta. 1079 (1): 29–38. PMID 1888762.
  • Bey F, Silva Pereira I, Coux O; et al. (1993). “The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family”. Mol. Gen. Genet. 237 (1–2): 193–205. PMID 7681138.
  • Kristensen P, Johnsen AH, Uerkvitz W; et al. (1995). “Human proteasome subunits from 2-dimensional gels identified by partial sequencing”. Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.
  • Kato S, Sekine S, Oh SW; et al. (1995). “Construction of a human full-length cDNA bank”. Gene. 150 (2): 243–50. PMID 7821789.
  • Nederlof PM, Wang HR, Baumeister W (1996). “Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro”. Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12060–4. PMID 8618844.
  • Bureau JP, Olink-Coux M, Brouard N; et al. (1997). “Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens”. Exp. Cell Res. 231 (1): 50–60. doi:10.1006/excr.1996.3453. PMID 9056411.
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). “HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation”. J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
  • Gerards WL, de Jong WW, Bloemendal H, Boelens W (1998). “The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits”. J. Mol. Biol. 275 (1): 113–21. doi:10.1006/jmbi.1997.1429. PMID 9451443.
  • Henry L, Baz A, Château MT; et al. (1998). “Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells”. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. 15 (3): 131–44. PMID 9497851.
  • Madani N, Kabat D (1998). “An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein”. J. Virol. 72 (12): 10251–5. PMID 9811770.
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). “Evidence for a newly discovered cellular anti-HIV-1 phenotype”. Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
  • Elenich LA, Nandi D, Kent AE; et al. (1999). “The complete primary structure of mouse 20S proteasomes”. Immunogenetics. 49 (10): 835–42. PMID 10436176.
  • Mulder LC, Muesing MA (2000). “Degradation of HIV-1 integrase by the N-end rule pathway”. J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419.
  • Kleijnen MF, Shih AH, Zhou P; et al. (2000). “The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome”. Mol. Cell. 6 (2): 409–19. PMID 10983987.
  • Feng Y, Longo DL, Ferris DK (2001). “Polo-like kinase interacts with proteasomes and regulates their activity”. Cell Growth Differ. 12 (1): 29–37. PMID 11205743.
  • Engidawork E, Juranville JF, Fountoulakis M; et al. (2002). “Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome”. J. Neural Transm. Suppl. (61): 117–30. PMID 11771738.
  • Sjakste T, Sjakste N, Scherrer K (2002). “Exon/intron organisation of human proteasome PROS-27 K gene”. DNA Seq. 12 (4): 261–5. PMID 11924531.

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