Palonosetron
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Palonosetron (INN, trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be better than granisetron.[1]
Palonosetron is administered intravenously, as a single dose, 30 minutes before chemotherapy,[2] or as a single oral capsule one hour before chemotherapy.[3] The oral formulation was approved on August 22, 2008 for prevention of acute CINV alone, as a large clinical trial did not show oral administration to be as effective as intravenous use against delayed CINV.[3]
References
References
- ↑ Billio, A; Morello, E; Clarke, MJ (Jan 20, 2010). “Serotonin receptor antagonists for highly emetogenic chemotherapy in adults”. The Cochrane database of systematic reviews (1): CD006272. doi:10.1002/14651858.CD006272.pub2. PMID 20091591.
- ↑ De Leon A (2006). “Palonosetron (Aloxi): a second-generation 5-HT(3) receptor antagonist for chemotherapy-induced nausea and vomiting”. Proceedings (Baylor University. Medical Center). 19 (4): 413–6. PMC 1618755. PMID 17106506.
- ↑ 3.0 3.1 Waknine, Yael (September 4, 2008). “FDA Approvals: Nplate, Aloxi, Vidaza”. Medscape. Retrieved 2008-09-04. Freely available with registration.
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