Pancreatic cancer history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S [2]

Overview

A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing pancreatic cancer. The most common symptoms of pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss, dark urine and light-colored or greasy stools.

History and Symptoms

A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing pancreatic cancer. The most common symptoms of pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss, dark urine and light-colored or greasy stools.

History

Patients with pancreatic cancer may have a positive history of:^[1]^[2]^[3]^[4]

Common Symptoms

Common symptoms of pancreatic cancer include:^[5]^[6]^[7]

Weight Loss (significant)
Jaundice
Midepigastric pain which may also radiate either to the lower back region and mid-back region
Nausea
Vomiting
Malaise
Fatigue
Loss of appetite
Anorexia
Dyspepsia
Ascites
Dark urine
Light-colored or greasy stools

Less Common Symptoms

Less common symptoms of pancreatic cancer include:^[3]^[8]^[9]

References

↑ Bosetti, C.; Lucenteforte, E.; Silverman, D. T.; Petersen, G.; Bracci, P. M.; Ji, B. T.; Negri, E.; Li, D.; Risch, H. A.; Olson, S. H.; Gallinger, S.; Miller, A. B.; Bueno-de-Mesquita, H. B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P. A.; Zatonski, W.; Fontham, E.; Bamlet, W. R.; Holly, E. A.; Bertuccio, P.; Gao, Y. T.; Hassan, M.; Yu, H.; Kurtz, R. C.; Cotterchio, M.; Su, J.; Maisonneuve, P.; Duell, E. J.; Boffetta, P.; La Vecchia, C. (2011). “Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)”. Annals of Oncology. 23 (7): 1880–1888. doi:10.1093/annonc/mdr541. ISSN 0923-7534.
↑ Go, Vay Liang W.; Gukovskaya, Anna; Pandol, Stephen J. (2005). “Alcohol and pancreatic cancer”. Alcohol. 35 (3): 205–211. doi:10.1016/j.alcohol.2005.03.010. ISSN 0741-8329.
↑ ^3.0 ^3.1 Li, Donghui (2012). “Diabetes and pancreatic cancer”. Molecular Carcinogenesis. 51 (1): 64–74. doi:10.1002/mc.20771. ISSN 0899-1987.
↑ Kirkegård, Jakob; Mortensen, Frank Viborg; Cronin-Fenton, Deirdre (2017). “Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis”. American Journal of Gastroenterology. 112 (9): 1366–1372. doi:10.1038/ajg.2017.218. ISSN 0002-9270.
↑ Vincent, Audrey; Herman, Joseph; Schulick, Rich; Hruban, Ralph H; Goggins, Michael (2011). “Pancreatic cancer”. The Lancet. 378 (9791): 607–620. doi:10.1016/S0140-6736(10)62307-0. ISSN 0140-6736.
↑ Schmidt-Hansen, Mia; Berendse, Sabine; Hamilton, William (2016). “Symptoms of Pancreatic Cancer in Primary Care”. Pancreas. 45 (6): 814–818. doi:10.1097/MPA.0000000000000527. ISSN 0885-3177.
↑ Holly, Elizabeth A.; Chaliha, Indranushi; Bracci, Paige M.; Gautam, Manjushree (2004). “Signs and symptoms of pancreatic cancer: a population-based case-control study in the San Francisco Bay area”. Clinical Gastroenterology and Hepatology. 2 (6): 510–517. doi:10.1016/S1542-3565(04)00171-5. ISSN 1542-3565.
↑ Kanji, Z. S.; Gallinger, S. (2013). “Diagnosis and management of pancreatic cancer”. Canadian Medical Association Journal. 185 (14): 1219–1226. doi:10.1503/cmaj.121368. ISSN 0820-3946.
↑ Yosipovitch, Gil (2010). “Chronic pruritus: a paraneoplastic sign”. Dermatologic Therapy. 23 (6): 590–596. doi:10.1111/j.1529-8019.2010.01366.x. ISSN 1396-0296.

Template:WikiDoc Sources

[BosettiLucenteforte2011-1] Bosetti, C.; Lucenteforte, E.; Silverman, D. T.; Petersen, G.; Bracci, P. M.; Ji, B. T.; Negri, E.; Li, D.; Risch, H. A.; Olson, S. H.; Gallinger, S.; Miller, A. B.; Bueno-de-Mesquita, H. B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P. A.; Zatonski, W.; Fontham, E.; Bamlet, W. R.; Holly, E. A.; Bertuccio, P.; Gao, Y. T.; Hassan, M.; Yu, H.; Kurtz, R. C.; Cotterchio, M.; Su, J.; Maisonneuve, P.; Duell, E. J.; Boffetta, P.; La Vecchia, C. (2011). “Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)”. Annals of Oncology. 23 (7): 1880–1888. doi:10.1093/annonc/mdr541. ISSN 0923-7534.

[GoGukovskaya2005-2] Go, Vay Liang W.; Gukovskaya, Anna; Pandol, Stephen J. (2005). “Alcohol and pancreatic cancer”. Alcohol. 35 (3): 205–211. doi:10.1016/j.alcohol.2005.03.010. ISSN 0741-8329.

[Li2012-3] 3.0 ^3.1 Li, Donghui (2012). “Diabetes and pancreatic cancer”. Molecular Carcinogenesis. 51 (1): 64–74. doi:10.1002/mc.20771. ISSN 0899-1987.

[KirkegårdMortensen2017-4] Kirkegård, Jakob; Mortensen, Frank Viborg; Cronin-Fenton, Deirdre (2017). “Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis”. American Journal of Gastroenterology. 112 (9): 1366–1372. doi:10.1038/ajg.2017.218. ISSN 0002-9270.

[VincentHerman2011-5] Vincent, Audrey; Herman, Joseph; Schulick, Rich; Hruban, Ralph H; Goggins, Michael (2011). “Pancreatic cancer”. The Lancet. 378 (9791): 607–620. doi:10.1016/S0140-6736(10)62307-0. ISSN 0140-6736.

[Schmidt-HansenBerendse2016-6] Schmidt-Hansen, Mia; Berendse, Sabine; Hamilton, William (2016). “Symptoms of Pancreatic Cancer in Primary Care”. Pancreas. 45 (6): 814–818. doi:10.1097/MPA.0000000000000527. ISSN 0885-3177.

[HollyChaliha2004-7] Holly, Elizabeth A.; Chaliha, Indranushi; Bracci, Paige M.; Gautam, Manjushree (2004). “Signs and symptoms of pancreatic cancer: a population-based case-control study in the San Francisco Bay area”. Clinical Gastroenterology and Hepatology. 2 (6): 510–517. doi:10.1016/S1542-3565(04)00171-5. ISSN 1542-3565.

[KanjiGallinger2013-8] Kanji, Z. S.; Gallinger, S. (2013). “Diagnosis and management of pancreatic cancer”. Canadian Medical Association Journal. 185 (14): 1219–1226. doi:10.1503/cmaj.121368. ISSN 0820-3946.

[Yosipovitch2010-9] Yosipovitch, Gil (2010). “Chronic pruritus: a paraneoplastic sign”. Dermatologic Therapy. 23 (6): 590–596. doi:10.1111/j.1529-8019.2010.01366.x. ISSN 1396-0296.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]