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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Papillary thyroid cancer classification

Introduction

Overview

Overview

Papillary thyroid cancer may be classified according to histological subtypes. The most common subtypes include conventional, follicular and tall cell form.

Classification

Classification

  • WHO classification of papillary thyroid cancer is as follows:[1]
    • Papillary microcarcinoma (<1 cm)
    • Encapsulated
    • Follicular
    • Diffuse sclerosing
    • Tall cell
    • Columnar cell
    • Cribriform-morular APC
    • Hobnail (micropapillary/discohesive)
    • Fibromatosis/ Fasciitis-like stroma
    • Solid/Trabecular
    • Oncocytic
    • Spindle cell
    • Clear cell
    • Warthin-like
  • Another classification system for papillary thyroid cancer is:[2]
    • Conventional
    • Follicular variant
    • Papillary microcarcinoma
    • Tall cell
    • Oncocytic
    • Columnar cell
    • Diffuse sclerosing
    • Solid
    • Clear cell
    • Cribriform morular
    • Macrofollicular
    • PTC with prominent hobnail features
    • PTC with fasciitis-like stroma
    • Combined papillary and medullary carcinoma
    • PTC with dedifferentiation to anaplastic carcinoma
  • The most common subtypes are:
    • Conventional
    • Follicular
    • Tall cell
Reference

Reference

  1. ↑ Kakudo, Kennichi; Bychkov, Andrey; Bai, Yanhua; Li, Yaqiong; Liu, Zhiyan; Jung, Chan Kwon (2018). “The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives”. Pathology International. doi:10.1111/pin.12737. ISSN 1320-5463.
  2. ↑ Lloyd, Ricardo V.; Buehler, Darya; Khanafshar, Elham (2011). “Papillary Thyroid Carcinoma Variants”. Head and Neck Pathology. 5 (1): 51–56. doi:10.1007/s12105-010-0236-9. ISSN 1936-055X.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Ammu Susheela, M.D. [3]