Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Paramethadione
Introduction
Overview
Overview
Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.[1]
Chemistry
Chemistry
Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.
- M.A. Spielman, Template:US Patent (1951).
References
References
- ↑ Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes – Retrieved January 2007.
External links
External links
- Template:DiseasesDB
- Hoffman, D; Chun A (1975). “Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose”. J Pharm Sci. 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]