Empiric treatment in most parts of the world would use a fluoroquinolone, most often ciprofloxacin. However, resistance to fluoroquinolones is highest in the Indian subcontinent and increasing in other areas. Injectable third-generation cephalosporins are often the empiric drug of choice when the possibility of fluoroquinolone resistance is high. Patients treated with an appropriate antibiotic may still require 3–5 days to defervesce completely, although the height of the fever decreases each day. Patients may actually feel worse when the fever starts to go away. If fever does not subside within 5 days, alternative antimicrobial agents or other foci of infection should be considered. Control requires treatment of antibiotics and vaccines prescribed by a doctor. Major control treatments for Paratyphoid fever include Ciprofloxacin for ten days or Ceftriaone/Cefotaxime for 14 days or Aziththromycin.

Paratyphoid B responds well to chloramphenicol or co-trimoxazole.

Chloramphenicol therapy is generally effective for Paratyphoid C.