Parotitis future or investigational therapies

Aprotinin, a kallikrein inhibitor, is currently being investigated for treatment of chronic parotitis symptoms. Initial studies have demonstrated its potential to relieve pain, restore normal parotid gland function, and resolve parotid gland swelling. Further research is warranted.

• Aprotinin, a kallikrein inhibitor, is currently being investigated for treatment of chronic parotitis symptoms.^[1]
  • Kallikrein release in the parotid gland is associated with the inflammatory edema process.
  • Aprotinin was administered to 7 recurrent parotitis patients, with the following results observed:
    • Pain relieved 12 hours after administration
    • Parotid gland function returned to normal 48 hours after administration
    • Parotid gland swelling resolved after 7 days.
• More research is warranted on the efficacy of kallikrein inhibition.

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