Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Paroxysmal cold hemoglobinuria overview
Introduction
Overview
Overview
Paroxysmal cold hemoglobinuria is a rare disease that is associated with intravascular hemolysis and hemoglobinuria after exposure to cold. The Donath-Landsteiner antibody sticks to the red blood cells in the cold which causes a complement-mediated lysis upon rewarming.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]