Paroxysmal nocturnal hemoglobinuria MRI

MRI may be helpful in diagnosing venous thrombosis which is often associated with PNH. MRI is also useful for assessing for splenomegaly.

There are no MRI findings associated with [PNH]. However, a MRI may be helpful in the diagnosis of complications of [PNH], which include:

• Renal cortical signal intensity loss secondary to hemosiderin accumulation in the renal cortex due to hemoglobinemia and haemoglobinuria.
• Hepatic and splenic signal intensity loss secondary to transfusional siderosis due to repeated blood transfusions.
• Intracranial thrombosis
• Splenic vein thrombosis
• Portal vein thrombosis
• Splenomegaly, which can be quantitated by MRI^[1]

• File:(Images shown below are courtesy of RadsWiki)
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